Search results for "Clinical Science and Care"

showing 2 items of 2 documents

Phenotyping of type 2 diabetes mellitus at onset on the basis of fasting incretin tone: Results of a two-step cluster analysis.

2015

Aims/Introduction According to some authors, in type 2 diabetes there is a reduced postprandial action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). However, little is known about the role of fasting incretins in glucose homeostasis. Our aim was to evaluate, through a two-step cluster analysis, the possibility of phenotyping patients with type 2 diabetes at onset on the basis of fasting GLP-1, GIP and ghrelin. Materials and Methods A total of 96 patients with type 2 diabetes within 6 months of onset (mean age 62.40 ± 6.36 years) were cross-sectionally studied. Clinical, anthropometric and metabolic parameters were evaluated. At fasting the follow…

Blood GlucoseMalemedicine.medical_treatmentEndocrinology Diabetes and MetabolismSettore MED/13 - Endocrinologiachemistry.chemical_compound0302 clinical medicineGlucagon-Like Peptide 1Glucose homeostasisCluster AnalysisHomeostasis030212 general & internal medicineGeneral MedicineArticlesMiddle AgedGlucagon-like peptide-1GhrelinGlucagon‐like peptide‐1PhenotypeClinical Science and CareFemaleOriginal Articlehormones hormone substitutes and hormone antagonistsGlucagon-like peptide-1medicine.medical_specialtyGlucose-dependent insulinotropic polypeptideIncretin030209 endocrinology & metabolismGastric Inhibitory PolypeptideGhrelin; Glucagon-like peptide-1; Glucose-dependent insulinotropic polypeptide; Endocrinology Diabetes and Metabolism; Internal MedicineIncretins03 medical and health sciencesInsulin resistanceGlucose‐dependent insulinotropic polypeptideInternal medicineDiabetes mellitusmedicineInternal MedicineHumansAgedAdiponectinbusiness.industryInsulinmedicine.diseaseEndocrinologyGlucosechemistryDiabetes Mellitus Type 2Glycated hemoglobinInsulin ResistancebusinessJournal of diabetes investigation
researchProduct

Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients

2021

Abstract Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m2), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosami…

Maleendocrine system diseasesEndocrinology Diabetes and MetabolismType 2 diabetesObesechemistry.chemical_compound0302 clinical medicineProspective Studies2. Zero hunger[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismeducation.field_of_studyDiabetesGeneral MedicineArticles[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMiddle AgedMagnetic Resonance ImagingFructosamineClinical Science and Care030220 oncology & carcinogenesisFructosamineFemalemedicine.medical_specialtyPopulationShort ReportAbdominal Fat030209 endocrinology & metabolismDiseases of the endocrine glands. Clinical endocrinologyFat mass03 medical and health sciencesDiabetes mellitusInternal medicineInternal MedicinemedicineHumansObesityeducationAgedGlycated Hemoglobinbusiness.industrynutritional and metabolic diseasesmedicine.diseaseRC648-665ObesityEndocrinologychemistryDiabetes Mellitus Type 2Glycated hemoglobinbusinessBody mass indexJournal of Diabetes Investigation
researchProduct